The classic formula. Botox injections are shots that use a toxin to prevent a muscle from moving for a limited time. The most common use of these injections is to relax the facial muscles that cause frown lines and other facial wrinkles.

The next generation. Xeomin is the second newest neuromuscular blocker on the market for various cosmetic and medical procedures. Xeomin is a purified form of botulinum toxin type A, while Botox is composed of a complex mixture of proteins. Essentially, this means that Xeomin doesn’t have any additives, while Botox does. This is often why Xeomin is nicknamed the “naked injectable.”

The newcomer. It has been used overseas for years, and now Letybo has finally made its way to the United States: The neuromodulator was approved by the FDA to treat glabellar lines (a.k.a. “11s,” or the area between the brows) last year.